Not too loose, not too tight - just right. Biphasic control of the Tsr HAMP domain

Not Too Hot, Not Too Cold: The Bundled-SVM is Just Right!

The Support Vector Machine (SVM) typically outperforms other algorithms on text classification problems, but requires training time roughly quadratic in the number of training documents. In contrast, linear time algorithms like Naive Bayes have lower performance, but can easily handle huge training sets. In this paper, we describe a technique that creates a continuum of classifiers between the ...

Not too late, not too fast!!

This editorial refers to ‘A simplified biventricular defibrillator with fixed long detection intervals reduces implantable cardioverter defibrillator (ICD) interventions and heart failure hospitalizations in patients with non-ischaemic cardiomyopathy implanted for primary prevention: the RELEVANT [Role of long dEtection window programming in patients with LEft VentriculAr dysfunction, Non-ische...

Not too much and not too little.

The structure and function of any protein is determined by its amino acid sequence. Thus, the substitution of one amino acid for another can alter the activity of a protein or its function. Mutations—or rather, polymorphism, once they become fixed in the population—can be deleterious, such that the altered protein is no longer able to fulfil its role with potentially devastating effects on the ...

The QT interval: too long, too short or just right.

Four Inches ! Too Close , Too Far , Just Right ?

The July 1992 Indoor Radon and Radon Decay Product Measurement Device Protocols, EPA 402-R-92-004 (EPA 1992) provides five measurement device location selection criteria that should be followed when placing a device within a room for measurement of the radon concentration. These criteria include: (1) a place where the device will not be disturbed and there is adequate room for the device, (2) a...